Reproduction Abstracts

Reprogramming of DNA methylation patterns in the early embryo is required for normal development. A longstanding paradigm of global loss of 5′-methylcytosine (5meC) over the first few cell-cycles of early development has recently been challenged (Li & O’Neill 2012, Li & O’Neill 2013)1,2. Here we show that immuno-detectable levels of 5meC and 5′-hydroxymethylcytosine (5hmC) persist throughout zygotic maturation and the first cell-cycles ...